abstract：BACKGROUND AND AIMS:We investigated placental histopathology for lesions that are associated with maternal and fetal circulation abnormalities in obese pregnant women with and without metabolic alterations. METHODS:332 pregnant women were divided into three groups: Group 1 included 163 non-obese metabolically healthy ...

journal_title：Atherosclerosis

authors： Bar J,Kovo M,Schraiber L,Shargorodsky M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Transient receptor potential vanilloid type 1 channel (TRPV1) is found to be expressed in endothelial cells (ECs) and activate endothelial nitric oxide synthase (eNOS). Recent studies implicate TRPV1 in attenuating inflammatory responses. However, the mechanisms underlying the beneficial effects rem...

journal_title：Atherosclerosis

authors： Wang Y,Cui L,Xu H,Liu S,Zhu F,Yan F,Shen S,Zhu M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The aim of this study was to investigate the impact of attenuated-signal plaque (ASP) observed by intravascular ultrasound (IVUS) on vessel response after drug-eluting stent implantation. METHODS:Data were derived from the IVUS cohort of the J-DESsERT trial comparing paclitaxel- and sirolimus-eluti...

journal_title：Atherosclerosis

authors： Kitahara H,Waseda K,Sakamoto K,Yamada R,Huang CC,Nakatani D,Sakata K,Kawarada O,Yock PG,Matsuyama Y,Yokoi H,Nakamura M,Muramatsu T,Nanto S,Fitzgerald PJ,Honda Y

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Carotid artery plaque is an established marker of subclinical atherosclerosis and common patho-mechanisms with coronary artery disease (CAD) are hypothesized. We aimed to identify genetic variants associated with carotid plaque and to examine the potential shared genetic basis with CAD. METHODS:Aft...

journal_title：Atherosclerosis

authors： Pott J,Burkhardt R,Beutner F,Horn K,Teren A,Kirsten H,Holdt LM,Schuler G,Teupser D,Loeffler M,Thiery J,Scholz M

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is the most common and severe autosomal dominant lipid metabolism dysfunction, which causes xanthoma, atherosclerosis and coronary heart disease. Earlier studies showed that mutations in LDLR, APOB and PCSK9 cause FH. Although more than 75% of the population in Eur...

journal_title：Atherosclerosis

authors： Xiang R,Fan LL,Lin MJ,Li JJ,Shi XY,Jin JY,Liu YX,Chen YQ,Xia K,Zhao SP

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Diabetes is a major risk factor for the development of atherosclerosis. Hyperglycemia stimulates vascular smooth muscle cells (VSMC) to secrete ligands that bind to the αVβ3 integrin, a receptor that regulates VSMC proliferation and migration. This study determined whether an antibody that had previ...

journal_title：Atherosclerosis

authors： Maile LA,Busby WH,Xi G,Gollahan KP,Flowers W,Gafbacik N,Gafbacik S,Stewart K,Merricks EP,Nichols TC,Bellinger DA,Clemmons DR

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Micro-particles (MP) are secreted by various cells. Their biological roles in health and in disease remain unknown. Here we describe formation of MP in the process of ABCA1-dependent cholesterol efflux in different cell types. METHODS:The ATP-binding cassette transporter, subfamily A, member 1 (ABC...

journal_title：Atherosclerosis

authors： Hafiane A,Genest J

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Mutations in the 5'-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. However, the role of purinergic receptor signaling in the pathology of intimal calcification is not well understood. In this study, we examined wh...

journal_title：Atherosclerosis

authors： Qian S,Regan JN,Shelton MT,Hoggatt A,Mohammad KS,Herring PB,Seye CI

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Depressed mood and exhaustion (DEEX) have gained attention as a risk predictor for cardiovascular disease (CVD). Studies to estimate its ranking in prediction models are sparse. METHODS:The study included 3428 men aged 45-74 years who participated in one of three population-based MONICA/KORA Augsbu...

journal_title：Atherosclerosis

authors： Ladwig KH,Baumert J,Marten-Mittag B,Lukaschek K,Johar H,Fang X,Ronel J,Meisinger C,Peters A,KORA Investigators.

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Sarpogrelate, a 5-hydroxytryptamine type 2A antagonist, is a potential antiplatelet agent. We performed a randomized study to evaluate the effect of sarpogrelate on vascular health in Korean patients with diabetes. METHODS:Forty diabetic patients aged 58.6 ± 6.8 years with 10-75% coronary artery st...

journal_title：Atherosclerosis

authors： Lee DH,Chun EJ,Hur JH,Min SH,Lee JE,Oh TJ,Kim KM,Jang HC,Han SJ,Kang DK,Kim HJ,Lim S

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endo...

journal_title：Atherosclerosis

authors： Tuttolomondo A,Casuccio A,Della Corte V,Maida C,Pecoraro R,Di Raimondo D,Vassallo V,Simonetta I,Arnao V,Pinto A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant accumulation of low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in the vessel walls. Previous studies clearly demonstrated an association specifica...

journal_title：Atherosclerosis

authors： Jeurissen MLJ,Walenbergh SMA,Houben T,Gijbels MJJ,Li J,Hendrikx T,Oligschlaeger Y,van Gorp PJ,Binder CJ,Donners MMPC,Shiri-Sverdlov R

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are major components of n-3 polyunsaturated fatty acids (n-3 PUFAs) which inhibit atherogenesis, although few studies have examined the effects of the combination of EPA and DHA on atherogenesis. The aim of this study was to investigate whet...

journal_title：Atherosclerosis

authors： Takashima A,Fukuda D,Tanaka K,Higashikuni Y,Hirata Y,Nishimoto S,Yagi S,Yamada H,Soeki T,Wakatsuki T,Taketani Y,Shimabukuro M,Sata M

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Decreased nitric oxide (NO) bioavailability and increased oxidative stress may be involved in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The relationship between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and CI-AKI is unknown. METHODS:We measur...

journal_title：Atherosclerosis

authors： Lu TM,Hsu CP,Chang CF,Lin CC,Lee TS,Lin SJ,Chan WL

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND AIMS:The exact mechanism of premature atherosclerosis in diabetes is still unclear. Inappropriate activation of the renin-aldosterone-angiotensin system may be an important risk factor for cardiovascular disease. We investigated whether renin and aldosterone are associated with vasoactive peptides midreg...

journal_title：Atherosclerosis

authors： Then C,Rottenkolber M,Lechner A,Meisinger C,Heier M,Koenig W,Peters A,Rathmann W,Bidlingmaier M,Reincke M,Seissler J

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces atherogenic lipoproteins and could lead to reduction of cardiovascular (CV) events. However, it is unclear whether blood PCSK9 levels predict future CV events. We performed a meta-analysis of all longitudinal studies to dete...

journal_title：Atherosclerosis

authors： Vlachopoulos C,Terentes-Printzios D,Georgiopoulos G,Skoumas I,Koutagiar I,Ioakeimidis N,Stefanadis C,Tousoulis D

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The European Society of Cardiology developed prediction models (SCORE) for low- and high-risk populations in the European countries. However, whether or not these models are valid in different ethnicities is unknown. We aimed to evaluate the performance of the low-risk SCORE model in the general Jap...

journal_title：Atherosclerosis

authors： Sawano M,Kohsaka S,Okamura T,Inohara T,Sugiyama D,Watanabe M,Nakamura Y,Higashiyama A,Kadota A,Okud N,Murakami Y,Ohkubo T,Fujiyoshi A,Miura K,Okayama A,Ueshima H,National Integrated Project for Prospective Observation of

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Carbohydrates and fat intake have both been linked to development of atherosclerosis. We examined associations between glycemic index (GI) and fat intake with carotid atherosclerosis. METHODS:The Atherosclerosis Risk in Communities (ARIC) cohort enrolled participants during the period 1987-1989 and...

journal_title：Atherosclerosis

authors： Dearborn JL,Qiao Y,Guallar E,Steffen LM,Gottesman RF,Zhang Y,Wasserman BA

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Mac-2 binding protein (M2BP) was reported to be a useful biomarker for liver fibrosis and malignant tumors. We hypothesized that expression of M2BP might also change in the process of atherosclerosis. METHODS:This study included subjects who visited our hospital for a physical checkup. RESULTS:The...

journal_title：Atherosclerosis

authors： Sugiura T,Dohi Y,Takase H,Yamashita S,Murai S,Tsuzuki Y,Ogawa S,Tanaka Y,Ohte N

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Previous epidemiological studies have shown positive associations between serum calcium concentration and risk of cardiovascular disease (CVD), but results differ by definition of CVD. We examined the association of circulating calcium with incident and fatal CVD, myocardial infarction (MI), and str...

journal_title：Atherosclerosis

authors： Rohrmann S,Garmo H,Malmström H,Hammar N,Jungner I,Walldius G,Van Hemelrijck M

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Galectin-3 binding protein (Gal-3BP) is a secreted protein associated with inflammation and carotid atherosclerosis. We hypothesized that high Gal-3BP levels may indicate unfavorable plaque morphology and outcome in coronary artery disease (CAD). METHODS:Gal-3BP plasma levels were measured by ELISA...

journal_title：Atherosclerosis

authors： Gleissner CA,Erbel C,Linden F,Domschke G,Akhavanpoor M,Doesch AO,Buss SJ,Giannitsis E,Katus HA,Korosoglou G

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Diabetic patients are at high risk of stroke and coronary artery disease. Recent data suggest that arachidonic acid metabolism is altered in diabetic conditions and that these alterations contribute to accelerated atherosclerosis. Little is known about how these alterations affect the metabolism and...

journal_title：Atherosclerosis

authors： Ménégaut L,Masson D,Abello N,Denimal D,Truntzer C,Ducoroy P,Lagrost L,Pais de Barros JP,Athias A,Petit JM,Martin L,Steinmetz E,Kretz B

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Studying atherosclerotic calcification in vivo requires mouse models with genetic modifications. Previous studies showed that injection of recombinant adeno-associated virus vector (AAV) encoding a gain-of-function mutant PCSK9 into mice promotes atherosclerosis. We aimed to study cardiovascular cal...

journal_title：Atherosclerosis

authors： Goettsch C,Hutcheson JD,Hagita S,Rogers MA,Creager MD,Pham T,Choi J,Mlynarchik AK,Pieper B,Kjolby M,Aikawa M,Aikawa E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Macrophage is a major contributor to the development of atherosclerosis by taking up deposited lipoprotein and eliciting local inflammation. Previously, we and others have shown C1q/TNF-related proteins (CTRPs) play diverse roles in vascular functions. In this study, we sought to investigate the cha...

journal_title：Atherosclerosis

authors： Wang XQ,Liu ZH,Xue L,Lu L,Gao J,Shen Y,Yang K,Chen QJ,Zhang RY,Shen WF

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND AIM:In the general population lipid-rich plaques are prone to rupture and healing of the plaque involves calcification. Patients undergoing hemodialysis have a severe derangement of mineral metabolism and calcification of the arterial tree may have different implications. METHODS:Between 2004 and 2005, ...

journal_title：Atherosclerosis

authors： Bellasi A,Ferramosca E,Ratti C,Block G,Raggi P

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Atherosclerosis is both a chronic inflammatory disease and a lipid metabolism disorder. C/EBPβ is well documented for its role in the development of hematopoietic cells and integration of lipid metabolism. However, C/EBPβ's role in atherosclerotic progression has not been examined. We assessed ...

journal_title：Atherosclerosis

authors： Rahman SM,Baquero KC,Choudhury M,Janssen RC,de la Houssaye BA,Sun M,Miyazaki-Anzai S,Wang S,Moustaid-Moussa N,Miyazaki M,Friedman JE

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Low ankle-brachial index (ABI) is associated with increased mortality and an increased incidence of cardiovascular events. The purpose of this study was to investigate the value of borderline ABI in predicting clinical outcomes. METHODS AND RESULTS:The data were derived from the Shinken Database 20...

journal_title：Atherosclerosis

authors： Tanaka S,Kaneko H,Kano H,Matsuno S,Suzuki S,Takai H,Otsuka T,Uejima T,Oikawa Y,Nagashima K,Kirigaya H,Sagara K,Yajima J,Sawada H,Aizawa T,Yamashita T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Abdominal aortic aneurysm (AAA) is characterized by vascular remodeling with increased infiltration of inflammatory cells and apoptosis/modulation of vascular smooth muscle cells (SMCs). Imatinib is a selective inhibitor of several tyrosine kinases, including PDGF receptors, Abl, and c-kit. The objective of ...

journal_title：Atherosclerosis

authors： Vorkapic E,Dugic E,Vikingsson S,Roy J,Mäyränpää MI,Eriksson P,Wågsäter D

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Treatment of severe peripheral arterial occlusive disease requires percutaneous revascularization. However, little is known about risk factors or predictors for reocclusion/restenosis. Cysteinyl leukotrienes are highly bioactive lipid mediators of inflammation. Their intravascular production may tak...

journal_title：Atherosclerosis

authors： Maga P,Sanak M,Rewerska B,Maga M,Jawien J,Wachsmann A,Rewerski P,Szczeklik W,Celejewska-Wójcik N

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH), which leads to premature cardiovascular events, still remains underrecognized and undertreated in most countries. Untreated FH individuals aged 20-39 years are at 100-fold higher risk of mortality from coronary heart disease compared to those of a general populati...

journal_title：Atherosclerosis

authors： Mickiewicz A,Chmara M,Futema M,Fijalkowski M,Chlebus K,Galaska R,Bandurski T,Pajkowski M,Zuk M,Wasag B,Limon J,Rynkiewicz A,Gruchala M

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Atherosclerosis is characterized by lipid accumulation and chronic inflammation in the arterial wall. Elevated levels of apolipoprotein (apo) B-containing lipoproteins are a risk factor for cardiovascular disease (CVD). By contrast, plasma levels of functional high-density lipoprotein (HDL) and apoA-I are pr...

journal_title：Atherosclerosis

authors： Hennuyer N,Duplan I,Paquet C,Vanhoutte J,Woitrain E,Touche V,Colin S,Vallez E,Lestavel S,Lefebvre P,Staels B

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Direct quantification of atherosclerotic plaque volume by three-dimensional vascular ultrasound (3DVUS) is more reproducible than 2DUS-based three-dimensional (2D/3D) techniques that generate pseudo-3D volumes from summed 2D plaque areas; however, its accuracy has not been reported. We aimed to determine 3...

journal_title：Atherosclerosis

authors： López-Melgar B,Fernández-Friera L,Sánchez-González J,Vilchez JP,Cecconi A,Mateo J,Peñalvo JL,Oliva B,García-Ruiz JM,Kauffman S,Jiménez-Borreguero LJ,Ruiz-Cabello J,Fernández-Ortiz A,Ibáñez B,Fuster V

更新日期：2016-05-01 00:00:00

abstract：AIMS:The ubiquitin-activating enzyme E1 (UBA1, E1), the apex of the ubiquitin proteasome pathway, plays a critical role in protein degradation and in pathological processes. Whether UBA1 participates the development of vascular restenosis remains unknown. This study aims to determine the role of UBA1 in the development...

journal_title：Atherosclerosis

authors： Qin Z,Cui B,Jin J,Song M,Zhou B,Guo H,Qian D,He Y,Huang L

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Vasa vasorum (VV) and lymphatic vasa vasorum (LVV) form their own networks in the adventitia. VV supply the aorta with nutrition and oxygen; however, the distribution and role of LVV remains to be determined. The purpose of this study was to investigate differences in the distribution of VV and LVV ...

journal_title：Atherosclerosis

authors： Sano M,Unno N,Sasaki T,Baba S,Sugisawa R,Tanaka H,Inuzuka K,Yamamoto N,Sato K,Konno H

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:γ-butyrobetaine (γBB) is a metabolite from dietary Carnitine, involved in the gut microbiota-dependent conversion from Carnitine to the pro-atherogenic metabolite trimethylamine-N-oxide (TMAO). Orally ingested γBB has a pro-atherogenic effect in experimental studies, but γBB has not been studied ...

journal_title：Atherosclerosis

authors： Skagen K,Trøseid M,Ueland T,Holm S,Abbas A,Gregersen I,Kummen M,Bjerkeli V,Reier-Nilsen F,Russell D,Svardal A,Karlsen TH,Aukrust P,Berge RK,Hov JE,Halvorsen B,Skjelland M

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Smoking affects the arterial wall and increases the risk of cardiovascular disease. It also affects the extracellular matrix in skin, causing impaired wound healing. However, little is known about putative molecular changes in the arterial wall. Our aim was to investigate the possible correlation between ext...

journal_title：Atherosclerosis

authors： Faarvang AS,Rørdam Preil SA,Nielsen PS,Beck HC,Kristensen LP,Rasmussen LM

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:We examined the associations between HbA1c levels and various atherosclerotic vascular parameters among adults without diabetes from the general population. METHODS:A total of 6500 community-dwelling adults, who were free of type 2 diabetes and ≥50 years of age, were included. High-resolution B-mode ultraso...

journal_title：Atherosclerosis

authors： Lee YH,Shin MH,Choi JS,Rhee JA,Nam HS,Jeong SK,Park KS,Ryu SY,Choi SW,Kim BH,Oh GJ,Kweon SS

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:HDL-C plasma levels are modulated by dietary fatty acid (FA), but studies investigating dietary supplementation in FA gave contrasting results. Saturated FA increased HDL-C levels only in some studies. Mono-unsaturated FA exerted a slight effect while poly-unsaturated FA mostly increased plasma HDL-C. AIMS:...

journal_title：Atherosclerosis

authors： Noto D,Fayer F,Cefalù AB,Altieri I,Palesano O,Spina R,Valenti V,Pitrone M,Pizzolanti G,Barbagallo CM,Giordano C,Averna MR

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The CAV1 gene encodes caveolin-1 expressed in cell types relevant to atherosclerosis. Cav-1-null mice showed a protective effect on atherosclerosis under the ApoE(-/-) background. However, it is unknown whether CAV1 is linked to CAD and MI in humans. In this study we analyzed a tagSNP for CAV1 in intron 2, r...

journal_title：Atherosclerosis

authors： Chen S,Wang X,Wang J,Zhao Y,Wang D,Tan C,Fa J,Zhang R,Wang F,Xu C,Huang Y,Li S,Yin D,Xiong X,Li X,Chen Q,Tu X,Yang Y,Xia Y,Xu C,Wang QK

更新日期：2016-03-01 00:00:00

abstract：AIMS:Besides carotid or cardiac embolism, stroke can occur via microangiopathy (small arterial disease [SAD]) and macroangiopathy (intracranial atherosclerotic stroke [ICAS]) of the intracranial vasculature. There have been efforts to identify risk factors specific to microangiopathy and macroangiopathy, including vasc...

journal_title：Atherosclerosis

authors： Bang OY,Chung JW,Ryoo S,Moon GJ,Kim GM,Chung CS,Lee KH

更新日期：2016-03-01 00:00:00